The Biochemistry of Alpha-2-Macroglobulin

Alpha-2-Macroglobulin (A2M), Amniotic Fluid

Sean O'Connell

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About this course

Sean O'Connell, Ph.D.describes the biochemistry of Alpha-2-Macroglobulin and its role in cartilage degeneration. Dr.O’Connelldescribes the role of Fibronectin Agrican Complex(FACTTest). The FACT acts as a biomarker for osteoarthritis in the complex interactions between Alpha 2 macroglobulin and osteoarthritis.

Dr. O'Connell is a seasoned healthcare professional with 30-years experience in regenerative medicine, immunology, cell biology, and tissue repair. As Founder and President of OConnell Consultants, LLC, Dr. O’Connell has served as interim management or strategic consultant to numerous venture capital, pharmaceutical, biotechnology, medical device, and tissue processing companies focusing on operations, pre-clinical and clinical development, commercial opportunity assessment, product and market development strategy. OCC clients have spanned early-stage start-up through large-cap companies. Dr. O’Connell is a partner in ICIG, an international catalyst partnership commercializing Cell therapies, medical inventions, and healthcare centers. Previously Dr. O’Connell has served as Chief Science Officer for Vertical Spine, LLC and as Chief Medical Officer for Cascade Medical Enterprises, LLC. As Director, Medical Affairs for the Transplantation/Tissue Engineering/Immunology Business Unit of Novartis Pharmaceuticals, Dr. O’Connell was responsible for pre-clinical and clinical development, publications and professional relations. Dr. O’Connell was SVP, Medical Direction, for Integrated Communications Corp. (ICC/IPG) and was COO and Co-Founder of Heartland BioTechnologies, LLC, a drug discovery start-up.

Dr. O’Connell received his Ph.D. in immunology and molecular biology from Rutgers University and the University of Medicine and Dentistry of New Jersey at New Brunswick. Additional post-graduate work includes post-doctoral fellowships at the Department of Toxicology, Rutgers University and the Center for Advanced Biotechnology and Medicine. Dr. O'Connell served as an Assistant Professor in the Department of Surgery, R. W. Johnson Medical School in New Brunswick where he was Head of the Surgical Oncology and Flow Cytometry & Immunology Laboratories. Dr. O'Connell received research grants from the New Jersey Cancer Commission, Sandoz/Novartis Pharmaceuticals and American Home Products involving studies in wound healing, host response to biomaterials, solid tumor-host immune response and graft versus host disease. Dr. O’Connell has authored over 60 peer-reviewed publications and abstracts and currently holds the position of Assistant Professor in the Department of Vascular Surgery, Englewood Hospital and Medical Center, Mount Sinai School of Medicine, New York.

Sean O’Connell, Ph.D.

President and Founder, O’Connell Consultants LLC

Topic(s) of Interest

Regenerative Medicine

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the "process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function".


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